Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | a Zn-chelator | Rattus norvegicus | |
InsL3 | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus | |
relaxin | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus | |
relaxin-3 | competitively inhibits the degradation of insulin, and crosslinking of insulin to IDE | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
InsL3 + H2O | Rattus norvegicus | - |
InsL3 fragments | - |
? | |
insulin + H2O | Rattus norvegicus | - |
insulin fragments | - |
? | |
relaxin + H2O | Rattus norvegicus | - |
relaxin fragments | - |
? | |
relaxin-3 + H2O | Rattus norvegicus | - |
relaxin-3 fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from liver by a series of chromatographic steps | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
additional information | IDE is a ubiquitously expressed metalloproteinase | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
InsL3 + H2O | - |
Rattus norvegicus | InsL3 fragments | - |
? | |
InsL3 + H2O | human substrate, degradation | Rattus norvegicus | InsL3 fragments | - |
? | |
insulin + H2O | - |
Rattus norvegicus | insulin fragments | - |
? | |
insulin + H2O | degradation | Rattus norvegicus | insulin fragments | - |
? | |
relaxin + H2O | - |
Rattus norvegicus | relaxin fragments | - |
? | |
relaxin + H2O | procine substrate, degradation | Rattus norvegicus | relaxin fragments | - |
? | |
relaxin-3 + H2O | - |
Rattus norvegicus | relaxin-3 fragments | - |
? | |
relaxin-3 + H2O | human substrate, degradation | Rattus norvegicus | relaxin-3 fragments | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000444 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | InsL3 | |
0.0000537 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | relaxin-3 | |
0.000182 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | relaxin |
General Information | Comment | Organism |
---|---|---|
physiological function | IDE is a ubiquitously expressed metalloproteinase responsible for the intracellular degradation of insulin, but possibly also for the cellular proteolysis of relaxin, InsL3 and relaxin-3 | Rattus norvegicus |