Literature summary for 3.4.24.56 extracted from

Zhao, J.; Li, L.; Leissring, M.A.
Insulin-degrading enzyme is exported via an unconventional protein secretion pathway (2009), Mol. Neurodegener., 4, 04.

Search for more literature for 3.4.24.56

Activating Compound

Activating Compound	Comment	Organism	Structure
A23187	calcium ionophore, increases extracellular IDE activity, but only under conditions that also elicit cytotoxicity	Mus musculus
A23187	calcium ionophore, increases extracellular IDE activity, but only under conditions that also elicit cytotoxicity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	IDE secretion is unaffected by the classical secretion inhibitors brefeldin A, monensin, or nocodazole. IDE secretion is similarly unaffected by multiple stimulators of protein secretion, including glyburide and 3'-O-(4-benzoyl)benzoyl-ATP	Mus musculus	-	-
extracellular	IDE secretion is unaffected by the classical secretion inhibitors brefeldin A, monensin, or nocodazole. IDE secretion is similarly unaffected by multiple stimulators of protein secretion, including glyburide and 3'-O-(4-benzoyl)benzoyl-ATP	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
hepatocyte	-	Mus musculus	-

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Release 2023.1 (January 2023)