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Literature summary for 3.4.24.56 extracted from

  • Bulloj, A.; Leal, M.C.; Surace, E.I.; Zhang, X.; Xu, H.; Ledesma, M.D.; Castano, E.M.; Morelli, L.
    Detergent resistant membrane-associated IDE in brain tissue and cultured cells: relevance to Abeta and insulin degradation (2008), Mol. Neurodegener., 3, 22.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
cholesterol membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form Mus musculus 5829
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cytosol cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form Rattus norvegicus 5829
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membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo Rattus norvegicus 16020
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membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo. Membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus 16020
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
brain membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus
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N2aEGFP cell N2a cells stably expressing the vector pEGFP Mus musculus
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N2aSW cell N2a cells stably expressing human amyloid prepcursor protein Swedish mutation Mus musculus
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Neuro-2a cell neuroblastoma cell Mus musculus
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neuron hippocampal neuron Rattus norvegicus
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