Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cholesterol | membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form | Mus musculus | 5829 | - |
cytosol | cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form | Rattus norvegicus | 5829 | - |
membrane | cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo | Rattus norvegicus | 16020 | - |
membrane | cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo. Membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE | Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE | Mus musculus | - |
N2aEGFP cell | N2a cells stably expressing the vector pEGFP | Mus musculus | - |
N2aSW cell | N2a cells stably expressing human amyloid prepcursor protein Swedish mutation | Mus musculus | - |
Neuro-2a cell | neuroblastoma cell | Mus musculus | - |
neuron | hippocampal neuron | Rattus norvegicus | - |