Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.56 extracted from

  • Leal, M.C.; Dorfman, V.B.; Gamba, A.F.; Frangione, B.; Wisniewski, T.; Castano, E.M.; Sigurdsson, E.M.; Morelli, L.
    Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology (2006), J. Neuropathol. Exp. Neurol., 65, 976-987.
    View publication on PubMed
Search for more literature for 3.4.24.56

Activating Compound

Activating Compound Comment Organism Structure
additional information fibrillar amyloid beta-peptide induces the enzyme in astrocytes through activation of a MAPK cascade via ERK1/2 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information Tg3576 transgenic mice express the Swedish mutant of amyloid beta-peptide, the expression and activity of IDE in the transgenic mice is increased with age around plaques as a component of astrocyte activation due to amyloid beta-peptide-triggered inflammation in contrast to the behaviour in Alzheimer mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta-peptide + H2O Mus musculus IDE is involved in clearance of amyloid-beta pepetide in the brain, enzyme deficiency may participate in the progression of Alzheimer's disease ?
-
 ?
insulin + H2O Mus musculus degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Mus musculus
-
brain mutant brains expressing the Swedish mutant precursor of amyloid beta-peptide, enzyme level, activity and distribution, immunohistochemic analysis, overview Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 quantitative enzyme expression analysis by comeptitive RT-PCR, age-related insulin degradation in trangenic mice, radiolabeled substrate, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-peptide + H2O degradation Mus musculus ?
-
 ?
amyloid beta-peptide + H2O IDE is involved in clearance of amyloid-beta pepetide in the brain, enzyme deficiency may participate in the progression of Alzheimer's disease Mus musculus ?
-
 ?
insulin + H2O degradation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IDE
-
 Mus musculus
Insulin-degrading enzyme
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus