Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.56 extracted from

  • Leissring, M.A.; Farris, W.; Wu, X.; Christodoulou, D.C.; Haigis, M.C.; Guarente, L.; Selkoe, D.J.
    Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria (2004), Biochem. J., 383, 439-446.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.56

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion isoform generated by translation of enzyme at an in-frame initiation codon 123 nucleotides upstream of the canonical translation start site, resulting in addition of a 41 amino acid N-terminal mitochondrial targeting sequence Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme can degrade cleaved mitochondrial targeting sequences, role of enzyme within mitochondria ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification for the mitochondrial isoform, mitochondrial targeting sequence of 41 amino acids is probably removed upon import into mitochondria Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme can degrade cleaved mitochondrial targeting sequences, role of enzyme within mitochondria Homo sapiens ?
-
 ?
peptide containing the mitochondrial targeting sequence of E1alpha subunit of human pyruvate dehydrogenase + H2O hydrolysis occurs at several sites Homo sapiens ?
-
 ?