Literature summary for 3.4.24.56 extracted from

Ebrahim, A.; Hamel, F.G.; Bennett, R.G.; Duckworth, W.C.
Identification of the metal associated with the insulin degrading enzyme (1991), Biochem. Biophys. Res. Commun., 181, 1398-1406.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	zinc and manganese are associated with the enzyme, with approximately 10times more zinc than manganese being present, one or both of these two metals are endogenously associated with this enzyme	Homo sapiens
Mn2+	zinc and manganese are associated with the enzyme, with approximately 10times more zinc than manganese being present, one or both of these two metals are endogenously associated with this enzyme	Rattus norvegicus
Zinc	zinc and manganese are associated with the enzyme, with approximately 10times more zinc than manganese being present, one or both of these two metals are endogenously associated with this enzyme	Homo sapiens
Zinc	zinc and manganese are associated with the enzyme, with approximately 10times more zinc than manganese being present, one or both of these two metals are endogenously associated with this enzyme	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Homo sapiens
partial	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
placenta	-	Homo sapiens	-
skeletal muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Insulin + H2O	-	Homo sapiens	Hydrolyzed insulin	-	?
Insulin + H2O	-	Rattus norvegicus	Hydrolyzed insulin	-	?

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Release 2023.1 (January 2023)