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Literature summary for 3.4.24.52 extracted from
- Neutralization of hemorrhagic snake venom metalloproteinase HR1a from Protobothrops flavoviridis by human monoclonal antibody (2008), Toxicon, 51, 345-352.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | specific monoclonal human antibodies HuMAbs neutralize the HR1a, determined by in vitro neutralization assay and by neutralization of the hemorrhagic activity, overview, from hybridoma from the fusion of SP2/0-Ag14 myeloma cells and spleen cells from KM mice immunized with purified HR1a, epitope mapping, overview | Protobothrops flavoviridis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Protobothrops flavoviridis | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Protobothrops flavoviridis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Protobothrops flavoviridis | the enzyme shows strong hemorrhagic activity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Protobothrops flavoviridis | - |
formerly Trimeresurus flavoviridis | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Protobothrops flavoviridis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Protobothrops flavoviridis | ? | - |
? | |
| additional information | the enzyme shows strong hemorrhagic activity | Protobothrops flavoviridis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | molecular modeling of the three-dimensional structure of the HR1a, overview | Protobothrops flavoviridis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HR1A | - |
Protobothrops flavoviridis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Protobothrops flavoviridis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Protobothrops flavoviridis |
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