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Literature summary for 3.4.24.35 extracted from

  • Aston-Mourney, K.; Zraika, S.; Udayasankar, J.; Subramanian, S.; Green, P.; Kahn, S.; Hull, R.
    Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide (2013), J. Biol. Chem., 288, 3553-3559.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP9, quantitative real-time PCR enzyme expression analysis Homo sapiens
gene MMP9, quantitative real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis Homo sapiens
additional information in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
GM6001
-
Homo sapiens
GM6001
-
Mus musculus
MMP-9 inhibitor I
-
Homo sapiens
MMP-9 inhibitor I
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
extracellular
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
?
-
?
Gelatin + H2O Mus musculus
-
?
-
?
Gelatin + H2O Mus musculus C57BL/6 x DBA/2
-
?
-
?
islet amyloid polypeptide + H2O Mus musculus enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide ?
-
?
islet amyloid polypeptide + H2O Homo sapiens enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide ?
-
?
islet amyloid polypeptide + H2O Mus musculus C57BL/6 x DBA/2 enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14780 gene MMP9
-
Mus musculus P41245 gene MMP9
-
Mus musculus C57BL/6 x DBA/2 P41245 gene MMP9
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
-
Homo sapiens
-
pancreatic islet
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O
-
Mus musculus ?
-
?
Gelatin + H2O
-
Mus musculus C57BL/6 x DBA/2 ?
-
?
islet amyloid polypeptide + H2O enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide Mus musculus ?
-
?
islet amyloid polypeptide + H2O enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide Homo sapiens ?
-
?
islet amyloid polypeptide + H2O enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide Mus musculus C57BL/6 x DBA/2 ?
-
?

Synonyms

Synonyms Comment Organism
gelatinase
-
Homo sapiens
gelatinase
-
Mus musculus
matrix metalloproteinase-9
-
Homo sapiens
matrix metalloproteinase-9
-
Mus musculus
MMP9
-
Homo sapiens
MMP9
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects down

General Information

General Information Comment Organism
malfunction in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis Homo sapiens
malfunction in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis Mus musculus
physiological function because islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects, islet MMP-9 activity may also be decreased in human type 2 diabetes, thereby contributing to increased islet amyloid deposition and beta-cell loss. Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide, the constituent of amyloid deposits in Alzheimer's disease Homo sapiens
physiological function matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide, the constituent of amyloid deposits in Alzheimer's disease Mus musculus