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Literature summary for 3.4.24.35 extracted from

  • Cha, M.C.; Purslow, P.P.
    The activities of MMP-9 and total gelatinase respond differently to substrate coating and cyclic mechanical stretching in fibroblasts and myoblasts (2010), Cell Biol. Int., 34, 587-591.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Rattus norvegicus
-
?
-
?
Fibronectin + H2O Rattus norvegicus
-
?
-
?
Laminin + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Rattus norvegicus
-
additional information MMP-9 activity is increased in fibroblasts when the cells are in contact with fibronectin and laminin, while in myoblasts, enhanced activity of the secreted enzyme occurs only in presence of collagen Rattus norvegicus
-
myoblast
-
Rattus norvegicus
-
Rat-2 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
Rattus norvegicus ?
-
?
Fibronectin + H2O
-
Rattus norvegicus ?
-
?
Laminin + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Rattus norvegicus
MMP-9
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus MMP-9 activity is increased in fibroblasts when the cells are in contact with fibronectin and laminin, while in myoblasts, enhanced activity of the secreted enzyme occurs only in presence of collagen up

General Information

General Information Comment Organism
metabolism activities of MMP-9 synthesized by fibroblasts tend to be regulated by the specific extracellular protein the cells are in contact with, whereas the gelatinolytic actions of proteases produced by myoblasts are more responsive to the mechanical deformation Rattus norvegicus