Literature summary for 3.4.24.35 extracted from

Chang, C.J.; Hsu, L.A.; Ko, Y.H.; Chen, P.L.; Chuang, Y.T.; Lin, C.Y.; Liao, C.H.; Pang, J.H.
Thrombin regulates matrix metalloproteinase-9 expression in human monocytes (2009), Biochem. Biophys. Res. Commun., 385, 241-246.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
monocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-9	-	Homo sapiens
MMP-9	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	thrombin stimulation induces MMP-9 secretion of monocytes dose- and time-dependently through activation of extracellular signaling-regulated protein kinase 1/2 and p38. Thrombin up-regulates mRNA and protein levels of MMP-9. NFkappaB activation is necessary for thrombin-induced MMP-9 upregulation in human monocytes. 1,2-bis (aminophenoxy) ethane-N,N,N',N'-tetraacetoxymethyl ester, a Ca2+ chelator, abolishes the thrombin-induced MMP-9 secretion	up

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Release 2023.1 (January 2023)