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Literature summary for 3.4.24.35 extracted from

  • Hamada, T.; Duarte, S.; Tsuchihashi, S.; Busuttil, R.W.; Coito, A.J.
    Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury (2009), Am. J. Pathol., 174, 2265-2277.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
macrophage
-
 Mus musculus
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neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 9
-
 Mus musculus
MMP-9
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the inability of iNOS-deficient mice to generate iNOS-derived nitric oxide profoundly inhibits MMP-9 activity in livers after ischemia/reperfusion injury, exposure of isolated murine neutrophils and macrophages to exogenous nitric oxide increases MMP-9 activity in both cell types, nitric oxide may activate MMP-9 in leukocytes by either autocrine or paracrine mechanisms down

General Information

General Information Comment Organism
physiological function MMP-9 activity induced by iNOS-derived NO leads to detachment of hepatocytes from the extracellular matrix and cell death, in addition to regulating leukocyte migration across extracellular matrix barriers Mus musculus