Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Melatonin | i.e. N-acetyl-5-methoxytryptamine, used in protection during gastric ulcer, arresting cell injury, protein carbonyl formation, and lipid peroxidation in mice during gastroprotection, inhibits MMP-9 expression and activity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | MMP-9 is secreted | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Zn2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
Gelatin + H2O | Mus musculus BALB/c | - |
? | - |
? | |
additional information | Mus musculus | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | ? | - |
? | |
additional information | Mus musculus BALB/c | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Purification (Comment) | Organism |
---|---|
native MMP-9 from gastric mucosa | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric ulcer | induced by ethanol | Mus musculus | - |
stomach | gastric mucosa | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
Gelatin + H2O | gelatin zymography, gelatin from porcine skin | Mus musculus | ? | - |
? | |
Gelatin + H2O | - |
Mus musculus BALB/c | ? | - |
? | |
Gelatin + H2O | gelatin zymography, gelatin from porcine skin | Mus musculus BALB/c | ? | - |
? | |
additional information | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | Mus musculus | ? | - |
? | |
additional information | MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview | Mus musculus BALB/c | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-9 | - |
Mus musculus |
MMP-9 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |