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Literature summary for 3.4.24.35 extracted from
- Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis (2007), Int. J. Cancer, 120, 1277-1283.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| platelet-activating factor | i.e. 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, induces MMP-9 enzyme expression, and increases enzyme content and activity | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | both NF-jB and AP-1 inhibitors inhibit MMP-9 expression | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Mus musculus | |
| Zn2+ | dependent on | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | Mus musculus | - |
? | - |
? | |
| additional information | Mus musculus | MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
female C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B16-F10 cell | murine melanoma cell line, with platelet-activating factor-induced experimental pulmonary metastasis, which is inhibited by both NF-jB and c-jun inhibitors and completelyby MMP-9 inhibitor | Mus musculus | - |
| blood vessel | in the walls | Mus musculus | - |
| bronchial epithelial cell | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
| Gelatin + H2O | gelatin zymography | Mus musculus | ? | - |
? | |
| additional information | MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-9 | - |
Mus musculus |
| MMP-9 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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