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Literature summary for 3.4.24.35 extracted from

  • Kolaczkowska, E.; Arnold, B.; Opdenakker, G.
    Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils (2008), Immunobiology, 213, 109-124.
    View publication on PubMed
Search for more literature for 3.4.24.35

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient MPP-9-/- mice show impaired neutrophil infiltration during zymosan peritonitis, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information epitope tagging of MMP-9 with monoclonal antibodies, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted enzyme Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus MMP-9 is essential for neutrophil infiltration during zymosan peritonitis ?
-
 ?
additional information Mus musculus C57BL/6 MMP-9 is essential for neutrophil infiltration during zymosan peritonitis ?
-
 ?
pro-urokinase + H2O Mus musculus
-
 active urokinase + prosequence of urokinase
-
 ?
pro-urokinase + H2O Mus musculus C57BL/6
-
 active urokinase + prosequence of urokinase
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte unstimulated/resident and inflammatory, peritoneal leukocytes, constitutive expression Mus musculus
-
macrophage secretion of MMP-9 in the early phase of peritonitis, no MMP-9 production in unstimulated macrophages Mus musculus
-
mast cell secretion of MMP-9 Mus musculus
-
additional information MMP-9 expression analysis in peritonitis, overview Mus musculus
-
neutrophil secretion of MMP-9, high MMP-9 expression in the early phase and especially in the late phase of peritonitis Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 coupled assay method using MMP-9 catalyzes activation of urokinase and susequent reaction of urokinase with the fluorogenic substrate S-2444 for spectrophotometric quantification, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MMP-9 is essential for neutrophil infiltration during zymosan peritonitis Mus musculus ?
-
 ?
additional information MMP-9 is essential for neutrophil infiltration during zymosan peritonitis Mus musculus C57BL/6 ?
-
 ?
pro-urokinase + H2O
-
 Mus musculus active urokinase + prosequence of urokinase
-
 ?
pro-urokinase + H2O
-
 Mus musculus C57BL/6 active urokinase + prosequence of urokinase
-
 ?

Synonyms

Synonyms Comment Organism
MMP-9
-
 Mus musculus