Literature summary for 3.4.24.35 extracted from

Martens, E.; Leyssen, A.; Van Aelst, I.; Fiten, P.; Piccard, H.; Hu, J.; Descamps, F.J.; Van den Steen, P.E.; Proost, P.; Van Damme, J.; Liuzzi, G.M.; Riccio, P.; Polverini, E.; Opdenakker, G.
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains (2007), Biochim. Biophys. Acta, 1770, 178-186.

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Cloned(Commentary)

Cloned (Comment)	Organism
expresssion of wild-type MMP-9 and truncated versions in insect cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
antibody REGA-3G12	highly selective, potent MMP-9 inhibition, the antibody recognizes the N-terminal part, not the C-terminal hemopexin and O-glycosylated domains, epitope mapping, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	a zinc metalloproteinase, contains one Zn2+ per enzyme molecule	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Gelatin + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14780	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	the enzyme is O-glycosylated at Trp116-Lys214 sequence of the C-terminal part	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?
Gelatin + H2O	gelatin zymography	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	epitope mapping, structure modeling, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-9	-	Homo sapiens
MMP-9	-	Homo sapiens

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Release 2023.1 (January 2023)