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Literature summary for 3.4.24.35 extracted from
- Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease (2008), Arthritis Rheum., 58, 854-863.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | MMP-9 is upregulated by tumor necrosis factor alpha, TNFalpha | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | MMP-9-deficient mice show eliminated elastin breakdown in coronary artery in the Kawasaki disease | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | Mus musculus | MMP-9 activity leads to elastin breakdown in an animal model of Kawasaki disease, a multisystem vasculitis leading to damage in the coronary circulationand aneurysm formation, overview | ? | - |
? |  |
| Gelatin + H2O | Mus musculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6, FVB/NJ, or MMP-9-/-, with FVB/NJ background, mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| coronary artery | coronary arteritis is induced by Lactobacillus casei cell wall extract injection | Mus musculus | - |
| heart | enzyme activity and expression analysis, overview | Mus musculus | - |
| vascular smooth muscle cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Elastin + H2O | - |
Mus musculus | ? | - |
? | |
| Elastin + H2O | MMP-9 activity leads to elastin breakdown in an animal model of Kawasaki disease, a multisystem vasculitis leading to damage in the coronary circulationand aneurysm formation, overview | Mus musculus | ? | - |
? | |
| Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
| Gelatin + H2O | gelatin zymography | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 9 | - |
Mus musculus |
| MMP-9 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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