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Literature summary for 3.4.24.35 extracted from

  • Rossello, A.; Nuti, E.; Orlandini, E.; Carelli, P.; Rapposelli, S.; Macchia, M.; Minutolo, F.; Carbonaro, L.; Albini, A.; Benelli, R.; Cercignani, G.; Murphy, G.; Balsamo, A.
    New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) (2004), Bioorg. Med. Chem., 12, 2441-2450.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-[(biphenyl-4-ylsulfonyl)(isobutyl)amino]-N-hydroxyacetamide 50% inhibition at 34 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2 Homo sapiens
Ag-3340 i.e. N-hydroxy-2,2-dimethyl-4-[(4-phenoxyphenyl)sulfonyl]thiomorpholine-3-carboxamide, 50% inhibition at 0.26 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2 Homo sapiens
CGS27023A 50% inhibition at 8 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2 Homo sapiens
N-hydroxy-2-(isobutyl[(4-methoxyphenyl)sulfonyl]amino)acetamide 50% inhibition at 2.9 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-