Application | Comment | Organism |
---|---|---|
medicine | neutrophils of patients with rheumatoid arthritis release considerable amounts of enzyme. Enzyme acts on fragments of collagen type II obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes. Lysines in the main immunodominant epitope are modified by partial hydroxylation and partial glycosylation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fragments of human collagen type II + H2O | fragments obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes | Homo sapiens | ? | - |
? |