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Literature summary for 3.4.24.29 extracted from

  • Jusko, M.; Potempa, J.; Kantyka, T.; Bielecka, E.; Miller, H.; Kalinska, M.; Dubin, G.; Garred, P.; Shaw, L.; Blom, A.
    Staphylococcal proteases aid in evasion of the human complement system (2014), J. Innate Immun., 6, 31-46.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.29

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Staphylococcus aureus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, metalloproteinase Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus V8-BC10
-
-
-

Synonyms

Synonyms Comment Organism
Aur
-
 Staphylococcus aureus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Staphylococcus aureus

General Information

General Information Comment Organism
metabolism four major extracellular proteases of Staphylococcus aureus are potent complement inhibitors: cysteine proteases staphopain A and staphopain B, the serine protease V8, and the metalloproteinase aureolysin cause a drastic decrease in the haemolytic activity of serum, whereas two serine-protease like enzymes, SplD and SplE, have no effect. The four enzymes inhibit all pathways of complement due to the efficient degradation of several crucial components Staphylococcus aureus
physiological function the enzyme acts as host complement inhibitor Staphylococcus aureus