Any feedback?
Literature summary for 3.4.24.24 extracted from
- Activity of matrix metalloproteinase-2 (MMP-2) in canine oronasal tumors (2007), Res. Vet. Sci., 82, 271-279.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the MMP-2/TIMP-2 ratio may be of value in evaluating the prognosis in canine oronasal cavity tumors | Canis lupus familiaris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-2 | - |
Canis lupus familiaris |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | MMP-2 is secreted | Canis lupus familiaris | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Canis lupus familiaris |  |
| Zn2+ | dependent on | Canis lupus familiaris | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | Canis lupus familiaris | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the proMMP-2 precursor form is cleaved by MT1-MMP to produce an intermediate MMP-2,subsequently, this molecule autocatalytically converts itself into mature MMP-2 | Canis lupus familiaris |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanoma cell | - |
Canis lupus familiaris | - |
| additional information | expression analysis of MMP-2 in dog tumor tissues, overview | Canis lupus familiaris | - |
| oronasal squamous cell carcinoma cell | regional lymph node invasion and distant metastases are more frequently observed in the MMP-2 positive cases, the MMP-2/TIMP-2 ratio is also positively correlated with MMP-2 activity, overview | Canis lupus familiaris | - |
| squamous cell carcinoma cell | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
| Gelatin + H2O | gelatin zymography | Canis lupus familiaris | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| matrix metalloproteinase-2 | - |
Canis lupus familiaris |
| MMP-2 | - |
Canis lupus familiaris |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
