Activating Compound | Comment | Organism | Structure |
---|---|---|---|
aminophenylmercuric acetate | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of the first, second, and third module, i.e. CBD1, CBD2 and CBD3 polypeptides, and of the fibronectin type-II-like modelues of MMP-2 in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CBD123 decreases active MMP-2 levels in HT-1080 cells, but only marginally the content of pro-MMP-2, overview | Homo sapiens | |
TIMP-2 | pro-MMP-2-TIMP-2 complexes are endocytosed into HT-1080 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | TSP-1 acts in LRP-mediated clearance of MMP-2, TIMP-2 complexing leads to MMP-2 accumulation in the cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant CBD1, CBD2 and CBD3 polypeptides and fibronectin type-II-like modelues of MMP-2 from Escherichia coli, by gelatin affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant MMP-2 | Homo sapiens | - |
HT-1080 cell | fibrosarcoma cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | gelatin zymography | Homo sapiens | ? | - |
? | |
additional information | TSP-1 acts in LRP-mediated clearance of MMP-2, TIMP-2 complexing leads to MMP-2 accumulation in the cells | Homo sapiens | ? | - |
? | |
additional information | the enzyme shows strong interaction with TSP-1 and CBD123, surface plasmon resonance analysis, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase A | - |
Homo sapiens |
matrix metalloprotenase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |