Literature summary for 3.4.24.24 extracted from

Sariahmetoglu, M.; Crawford, B.D.; Leon, H.; Sawicka, J.; Li, L.; Ballermann, B.J.; Holmes, C.; Berthiaume, L.G.; Holt, A.; Sawicki, G.; Schulz, R.
Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation (2007), FASEB J., 21, 2486-2495.

Search for more literature for 3.4.24.24

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens
Zn2+	a zinc-endopeptidase	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
64000	-	x * 72000, native proMMP-2, x * 64000, recombinant MMP-2	Homo sapiens
72000	-	x * 72000, native proMMP-2, x * 64000, recombinant MMP-2	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Gelatin + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08253	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	proMMP-2 contains 29 potential phosphorylation sites, that at least five of these sites are phosphorylated, purified MMP-2 is phosphorylated by protein kinase C in vitro, peptide mass fingerprint for phosphorylation site determination, overview	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HT-1080 cell	-	Homo sapiens	-
additional information	ubiquitous expression of MMP-2	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 72000, native proMMP-2, x * 64000, recombinant MMP-2	Homo sapiens
More	proMMP-2 consists of a signal peptide, a pro-peptide, a collagenase-like domain 1, a collagen-binding domain, a collagenase-like domain 2, and a hemopexin-like domain	Homo sapiens

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-2	-	Homo sapiens
MMP-2	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	7.6	assay at	Homo sapiens

pI Value

Organism	Comment	pI Value Maximum	pI Value
Homo sapiens	2D electrophoresis	-	5.64

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Release 2023.1 (January 2023)