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Literature summary for 3.4.24.24 extracted from

  • Mountain, D.J.; Singh, M.; Menon, B.; Singh, K.
    Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs (2007), Am. J. Physiol. Cell Physiol., 292, C867-C875.
    View publication on PubMed
Search for more literature for 3.4.24.24

Activating Compound

Activating Compound Comment Organism Structure
interleukin 1beta increases enzyme expression and activity in cardiac microvascular endothelial cells, involvement of PKC and/or MAPK signaling cascades, overview, the activation is inhibited by 52% by Gö6976, a PKC inhibitor, at 100 nM, while inhibitors SN50 and SP600125 have no effect on the activation Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cardiac Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
microvascular endothelial cell
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 quantitative MMP-2 expression analysis of untreated and induced cells, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O gelatin zymography Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-2
-
 Rattus norvegicus
MMP-2
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Rattus norvegicus