Protein Variants | Comment | Organism |
---|---|---|
E404A | no enzymic activity, competition with isolated collagen-binding domain and with matrix metalloproteinase MMP-9 binding to native and denatured type I collagen | Homo sapiens |
additional information | recombinant enzyme lacking collagen-binding domain, does not block binding to gelatin of either enzyme mutant E404A or matrix metalloproteinase MMP-9 mutant E402A | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47052 | - |
x * 66000, SDS-PAGE, x * 66518, calculated, enzyme mutant E404A, x * 59000, SDS-PAGE, x * 47052, calculated, enzyme mutant lacking collagen-binding domain | Homo sapiens |
59000 | - |
x * 66000, SDS-PAGE, x * 66518, calculated, enzyme mutant E404A, x * 59000, SDS-PAGE, x * 47052, calculated, enzyme mutant lacking collagen-binding domain | Homo sapiens |
66000 | - |
x * 66000, SDS-PAGE, x * 66518, calculated, enzyme mutant E404A, x * 59000, SDS-PAGE, x * 47052, calculated, enzyme mutant lacking collagen-binding domain | Homo sapiens |
66518 | - |
x * 66000, SDS-PAGE, x * 66518, calculated, enzyme mutant E404A, x * 59000, SDS-PAGE, x * 47052, calculated, enzyme mutant lacking collagen-binding domain | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | collagen binding domains of matrix metalloproteinases MMP-2 and MMP-9 bind the same or closely positioned sites on type I collagen | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | collagen binding domains of matrix metalloproteinases MMP-2 and MMP-9 bind the same or closely positioned sites on type I collagen | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 66000, SDS-PAGE, x * 66518, calculated, enzyme mutant E404A, x * 59000, SDS-PAGE, x * 47052, calculated, enzyme mutant lacking collagen-binding domain | Homo sapiens |