Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
perlecan + H2O | Homo sapiens | i.e. HSPG2, a large heparan sulfate proteoglycan, expressed in the basement membrane underlying epithelial and endothelial cells, proteolytic degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell line | invasive prostate cancer cells, high enzyme expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
perlecan + H2O | i.e. HSPG2, a large heparan sulfate proteoglycan, expressed in the basement membrane underlying epithelial and endothelial cells, proteolytic degradation | Homo sapiens | ? | - |
? | |
perlecan + H2O | high activity, the enzyme produces discrete perlecan fragments corresponding to an origin in immunoglobulin repeat region domain IV, the enzyme cleaves every subpart of recombinantly generated perlecan domain IV. Identification and characterization of perlecan Dm IV-3 sites of cleavage by enzyme MMP-7, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | a long C-terminal portion of perlecan domain IV, DmIV-3, induces a strong clustering phenotype in the metastatic PCa cell lines, PC-3 and C4-2. MMP-7 digestion of Dm IV-3 reverses the clustering effect into one favoring cell dispersion, pro-metastasis effects of MMP-7 on prostate cancer cells | Homo sapiens |