Literature summary for 3.4.24.23 extracted from

Heinz, A.; Taddese, S.; Sippl, W.; Neubert, R.H.; Schmelzer, C.E.
Insights into the degradation of human elastin by matrilysin-1 (2011), Biochimie, 93, 187-194.

Search for more literature for 3.4.24.23

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc-dependent	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
elastin + H2O	Homo sapiens	degradation	elastin peptides	in the range of 500-8000 Da	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
elastin + H2O	degradation	Homo sapiens	elastin peptides	in the range of 500-8000 Da	?
elastin + H2O	degradation. MMP-7 mainly cleaves in N- and C-terminal regions of elastin's precursor, which involves linkages in domains encoded by exons 2, 3, 5-7, 26, and 30-33. Only few cleavages occur in the central part of the precursor and no cleavages in regions in elastin that are involved in cross-linking. MMP-7 shows a strong preference for Leu in P1' and also accepts Val, Gly, and Pro at this position, whereas Ala is not preferred at P1', molecular modeling, overview. Not only the size of the amino acid residue in P1' but also the orientation of the neighboring P1 residue and, thus, the orientation of the peptide bond that is cleaved influences the cleavage preference of MMP-7, cleavage site specificity of MMP-7 in human skin elastin, overview	Homo sapiens	elastin peptides	in the range of 500-8000 Da	?
additional information	two substrate peptides present in human skin elastin: PGGLAG, residues 67-72, containing Leu at P1', and LGGAGQ, residues 754-759, containing Ala at P1', and two further peptides PGGAAG and PGGGAG are modeled and docked into the MMP-7 catalytic site. The binding site was defined on the zinc ion	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matrilysin-1	-	Homo sapiens
MMP-7	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	human matrilysin-1 is one of the most potent elastases besides macrophage elastase in the family of matrix metalloproteinases	Homo sapiens

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Release 2023.1 (January 2023)