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Literature summary for 3.4.24.23 extracted from

  • Gogly, B.; Fournier, B.; Couty, L.; Naveau, A.; Brasselet, C.; Durand, E.; Coulomb, B.; Lafont, A.
    Gingival fibroblast inhibits MMP-7: evaluation in an ex vivo aorta model (2009), J. Mol. Cell. Cardiol., 47, 296-303.
    View publication on PubMed
Search for more literature for 3.4.24.23

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1 from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular MMP-7 is secreted from fibroblasts Oryctolagus cuniculus
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additional information TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites Oryctolagus cuniculus
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast aortic and adventitial Oryctolagus cuniculus
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additional information no MMP-7 in gingival fibroblasts isolated and cultured from gingiva. Coculture of aorta fiboblasts with fibroblasts from gingiva lead to inhibition of the secreted MMP-7 and reduction of its level at least in part due to the formation of MMP-7/TIMP-1 complexes, after 21 days MMP-7 is completely inhibited, the effect is less with dermal fibroblasts, overview. siRNA TGF-beta1 inhibits the inhibition efficiency of GF on MMP-7 Oryctolagus cuniculus
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Synonyms

Synonyms Comment Organism
MMP-7
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 Oryctolagus cuniculus

Expression

Organism Comment Expression
Oryctolagus cuniculus TIMP-1 from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity. TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites down