Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | primary, monocyte-derived | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | infection by Mycobacterium tuberculosis upregulates MMP-7 expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | matrix metalloproteinase-7 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade. The induction is not inhibited by p-aminosalicyclic acid, an agent used to treat drug-resistant tuberculosis. The p38 MAPK pathway regulates the divergence between MMPs and TIMP-1 | Homo sapiens |
physiological function | matrix metalloproteinase-7 degrades the extracellular matrix and is implicated in tuberculosis-driven tissue destruction, signaling pathways regulating macrophage MMP-7 in human pulmonary tuberculosis, overview | Homo sapiens |