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Literature summary for 3.4.24.23 extracted from

  • Ryu, H.Y.; Lee, J.; Yang, S.; Park, H.; Choi, S.; Jung, K.C.; Lee, S.T.; Seong, J.K.; Han, I.O.; Oh, E.S.
    Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells (2009), J. Biol. Chem., 284, 35692-35701.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface syndecan-2 functions as a cell surface docking receptor for pro-MMP-7, overview Homo sapiens 9986
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extracellular MMP-7 is secreted, which is enhanced by syndecan-2 Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, MMP-7 causes extracellular shedding of syndecan-2, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification syndecan-2 potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colonic adenocarcinoma cell
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Homo sapiens
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colonic cancer cell
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Homo sapiens
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epithelium
-
Homo sapiens
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HT-29 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, MMP-7 causes extracellular shedding of syndecan-2, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
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Homo sapiens
MMP-7
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, overview up