Activating Compound | Comment | Organism | Structure |
---|---|---|---|
syndecan-2 | enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | syndecan-2 functions as a cell surface docking receptor for pro-MMP-7, overview | Homo sapiens | 9986 | - |
extracellular | MMP-7 is secreted, which is enhanced by syndecan-2 | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, MMP-7 causes extracellular shedding of syndecan-2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09237 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | syndecan-2 potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic adenocarcinoma cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, MMP-7 causes extracellular shedding of syndecan-2, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, overview | up |