Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.23 extracted from

  • Ogden, S.R.; Noto, J.M.; Allen, S.S.; Patel, D.A.; Romero-Gallo, J.; Washington, M.K.; Fingleton, B.; Israel, D.A.; Lewis, N.D.; Wilson, K.T.; Chaturvedi, R.; Zhao, Z.; Shyr, Y.; Peek, R.M.
    Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice (2010), Cancer Res., 70, 30-35.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric epithelial cell
-
 Mus musculus
-
stomach
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Mus musculus
MMP-7
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus Helicobacter pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro up

General Information

General Information Comment Organism
malfunction MMP-7 is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and Helicobacter pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro, that may serve to protect the gastric mucosa from pathophysiologic processes which promote carcinogenesis. Enhanced gastritis in Helicobacter pylori–infected mmp-7-knockout mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7-mediated bacterial eradication Mus musculus