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Literature summary for 3.4.24.23 extracted from
- Characterization of rat uterine matrilysin and its cDNA. Relationship to human pump-1 and activation of procollagenases (1995), J. Biol. Chem., 270, 16016-16022.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hydroxamate | - |
Rattus norvegicus |  |
| Pseudopeptide inhibitors | - |
Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | cleaves the alpha2(I) chain of rat gelatin producing major cuts at Gly713-Ile714, Gly775-Leu776, Gly809-Ile810 | Rattus norvegicus | ? | - |
? | |
| additional information | rat and human enzyme do not activate rat collagenase 3 | Rattus norvegicus | ? | - |
? | |
| additional information | maximum activation of human interstitial collagenase 1 (pro-matrix metalloproteinase 1) when added in presence of 4-aminophenylmercuric acetate by cleaving the Gln80-Phe81 bond | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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