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Literature summary for 3.4.24.23 extracted from
- Purification and properties of a small latent matrix metalloproteinase of the rat uterus (1988), J. Biol. Chem., 263, 16918-16925.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Rattus norvegicus |  |
| DTT | - |
Rattus norvegicus | |
| additional information | not: phosphoramidon; Zincov | Rattus norvegicus | |
| Ovostatin | - |
Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Rattus norvegicus | |
| Co2+ | partial activation | Rattus norvegicus | |
| Sr2+ | partial activation | Rattus norvegicus | |
| Zinc | zinc is the metal at the active center | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14000 | - |
rat, active form, gel filtration | Rattus norvegicus |
| 19000 | - |
x * 19000, active form, SDS/DTT-PAGE | Rattus norvegicus |
| 26000 | - |
rat, latent form, gel filtration | Rattus norvegicus |
| 28000 | - |
x * 28000, latent form, SDS/DTT-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Azocoll + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Dinitrophenyl-Pro-Leu-Gly-Ile-Ala-Gly-Pro-D-Arg + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Fibronectin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Gelatin + H2O | type III | Rattus norvegicus | ? | - |
? | |
| Gelatin + H2O | type IV | Rattus norvegicus | ? | - |
? | |
| Gelatin + H2O | type V | Rattus norvegicus | ? | - |
? | |
| Gelatin + H2O | digests the alpha2(I) chain of gelatin in preference to the alpha1(I) chain | Rattus norvegicus | ? | - |
? | |
| Gelatin + H2O | type I | Rattus norvegicus | ? | - |
? | |
| Insulin B-chain + H2O | cleavage at 2 points: Ala14-Leu15 and Tyr16-Leu17 | Rattus norvegicus | ? | - |
? | |
| additional information | phenylazo-Pro-Leu-Gly-Pro-D-Arg | Rattus norvegicus | ? | - |
? | |
| additional information | collagens of type I, III or V | Rattus norvegicus | ? | - |
? | |
| Proteoglycan + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 19000, active form, SDS/DTT-PAGE | Rattus norvegicus |
| ? | x * 28000, latent form, SDS/DTT-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
azocoll, proteoglycan | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 8.8 | 5.5: about 30% of activity maximum, 8.8: about 40% of activity maximum | Rattus norvegicus |
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