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Literature summary for 3.4.24.22 extracted from

  • Saunders, W.B.; Bayless, K.J.; Davis, G.E.
    MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices (2005), J. Cell Sci., 118, 2325-2340.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matrix metalloproteinase MMP-1 zymogen activation by enzyme and other serine proteases is central to endothelial cell-mediated collagen degradation and capillary tube regression in 3D collagen matrices ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activation of proenzyme by serine proteases such as plasma kallikrein, trypsin, neutrophil elastase, cathepsin G, tryptase or chymase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
endothelium proenzyme expression is markedly induced in endothelial cells undergoing capillary tube morphogenesis. Enzyme-induced activation of matrix metalloproteinase MMP-1 correlates with tube regression and gel contraction Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matrix metalloproteinase MMP-1 zymogen activation by enzyme and other serine proteases is central to endothelial cell-mediated collagen degradation and capillary tube regression in 3D collagen matrices Homo sapiens ?
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 ?
proMMP-1 + H2O
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 Homo sapiens MMP-1 + propeptide
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 ?