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Literature summary for 3.4.24.18 extracted from

  • Niyitegeka, J.M.; Bastidas, A.C.; Newman, R.H.; Taylor, S.S.; Ongeri, E.M.
    Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury (2015), Am. J. Physiol. Renal Physiol., 308, F56-68.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.18

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten enzyme kinetics, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border membrane
-
 Mus musculus 31526
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein kinase A + H2O Mus musculus the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney the enzyme is abundantly expressed in the brush border membranes of kidney proximal tubules. Localization of meprin A in the glomeruli of diabetic kidneys Mus musculus
-
renal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein kinase A + H2O the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview Mus musculus ?
-
 ?
protein kinase A catalytic subunit Cbeta1 + H2O the enzyme cleaves at defined sites, cytosolic-enriched kidney proteins from meprin alphabeta double knockout mice, and purified forms of recombinant mouse PKA Calpha, Cbeta1, and Cbeta2, are incubated with activated forms of either homomeric meprinA or meprin B, EC 3.4.24.63, product analysis by mass spectrometry, overview. Meprin A only cleaves PKA Cbeta1 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
meprin metalloprotease
-
 Mus musculus

General Information

General Information Comment Organism
physiological function meprins may impact kidney injury, in part, via modulation of protein kinase A signaling pathways, meprins are implicated in ischemia-reperfusion-induced renal injury and diabetic nephropathy. Meprin cleavage decreases the kinase activity of protein kinase A subunits Calpha, Cbeta1, and Cbeta2 Mus musculus