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Literature summary for 3.4.24.18 extracted from

  • Ohler, A.; Debela, M.; Wagner, S.; Magdolen, V.; Becker-Pauly, C.
    Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation (2010), Biol. Chem., 391, 455-460.
    View publication on PubMed
Search for more literature for 3.4.24.18

Activating Compound

Activating Compound Comment Organism Structure
KLK4 activator of meprin beta Homo sapiens
KLK5 activator of meprin alpha and beta Homo sapiens
KLK8 activator of meprin beta Homo sapiens
additional information alpha- and beta-tryptase, urokinase plasminogen activator, KLK2, KLK6, KLK7, and KLK11 do not activate meprin alpha and beta Homo sapiens
neutrophil elastase activator of meprin alpha Homo sapiens
plasmin activator of meprin alpha Homo sapiens
Trypsin activator of meprin alpha and beta Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen type IV + H2O Homo sapiens meprin alpha can degrade collagen type IV ?
-
 ?
interleukin-1beta + H2O Homo sapiens meprin beta activates interleukin 18 ?
-
 ?
procollagen III + H2O Homo sapiens meprin alpha can process procollagen III ?
-
 ?
tissue growth factor-alpha + H2O Homo sapiens meprin alpha can process tissue growth factor-alpha ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale, whereas meprin beta is restricted to the cells of the stratum granulosum Homo sapiens
-
skin in skin, meprins are located in separate layers of human epidermis Homo sapiens
-
stratum basale in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale Homo sapiens
-
stratum granulosum in human epidermis, meprin beta is restricted to the cells of the stratum granulosum Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen type IV + H2O meprin alpha can degrade collagen type IV Homo sapiens ?
-
 ?
interleukin-1beta + H2O meprin beta activates interleukin 18 Homo sapiens ?
-
 ?
pro-KLK7 + H2O meprin beta cleaves pro-KLK7 between Gly17 and Asp18 Homo sapiens KLK7 + ?
-
 ?
procollagen III + H2O meprin alpha can process procollagen III Homo sapiens ?
-
 ?
tissue growth factor-alpha + H2O meprin alpha can process tissue growth factor-alpha Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
meprin alpha
-
 Homo sapiens
meprin beta
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function meprin beta induces a dramatic change in cell morphology and a significant reduction in cell number, whereas meprin alpha plays a role for basal keratinocyte proliferation in vitro Homo sapiens