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Literature summary for 3.4.24.18 extracted from

  • Banerjee, S.; Oneda, B.; Yap, L.M.; Jewell, D.P.; Matters, G.L.; Fitzpatrick, L.R.; Seibold, F.; Sterchi, E.E.; Ahmad, T.; Lottaz, D.; Bond, J.S.
    MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease (2009), Mucosal Immunol., 2, 220-231.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine genetic association of gene MEP1A encoding the alpha-subunit of meprin A with inflammatory bowel disease in patients with ulcerative colitis. Meprin-alpha mRNA is decreased in inflamed mucosa of patients with ulcerative colitis Homo sapiens
medicine meprin A subunit alpha knock-out mice exhibit a more severe intestinal injury and inflammation than their wild-type counterparts following oral administration of dextran sulfate sodium Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information meprin A subunit alpha knock-out mice exhibit a more severe intestinal injury and inflammation than their wild-type counterparts following oral administration of dextran sulfate sodium Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16819
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Mus musculus P28825
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-

Source Tissue

Source Tissue Comment Organism Textmining
intestine intestinal epithelium Homo sapiens
-