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Literature summary for 3.4.24.18 extracted from

  • Kruse, M.; Becker, C.; Lottaz, D.; Koehler, D.; Yiallouros, I.; Krell, H.; Sterchi, E.E.; Stoecker, W.
    Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors (2004), Biochem. J., 378, 383-389.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Homo sapiens
batimastat
-
Homo sapiens
captopril
-
Homo sapiens
galardin
-
Homo sapiens
L-Pro-L-Leu-Gly-hydroxamate
-
Homo sapiens
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
-
Homo sapiens
Ro 32-7315
-
Homo sapiens
TAPI-0 i.e. tumour necrosis factor alpha protease inhibitor-0 Homo sapiens
TAPI-2 i.e. tumour necrosis factor alpha protease inhibitor-2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen IV + H2O
-
Homo sapiens ?
-
?
Fibronectin + H2O cleavage at positions Y294-Q295, N709-T210 and in the linker regions between fibronectin type I repeats 5 and 6 and fibronectin type II repeats 1 and 2 Homo sapiens ?
-
?
additional information no substrate: intact collagen I Homo sapiens ?
-
?
nidogen-1 + H2O cleavage at D67-R68 and Q363-H364 Homo sapiens ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00002
-
actinonin pH 7.5, 37°C Homo sapiens
0.00017
-
galardin pH 7.5, 37°C Homo sapiens
0.0004
-
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid pH 7.5, 37°C Homo sapiens
0.00053
-
L-Pro-L-Leu-Gly-hydroxamate pH 7.5, 37°C Homo sapiens
0.0015
-
TAPI-2 pH 7.5, 37°C Homo sapiens
0.0016
-
Ro 32-7315 pH 7.5, 37°C Homo sapiens
0.0022
-
TAPI-0 pH 7.5, 37°C Homo sapiens
0.0044
-
batimastat pH 7.5, 37°C Homo sapiens
0.074
-
captopril pH 7.5, 37°C Homo sapiens