Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetyl-Arg-Pro-Gly-Tyr hydroxamate | kinetics | Mus musculus | |
actinonin | i.e. 3-[[1-[[2-(hydroxymethyl)-1-pyrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octano hydroxamic acid, strong, kinetics | Mus musculus | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Glu-Pro-Phe-Arg | - |
Mus musculus | |
Hydroxamyl-succinyl-Pro-Phe-Arg | kinetics | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.174 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Arg-Pro-Phe-Arg | - |
Mus musculus | |
0.182 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Lys-Pro-Phe-Arg | - |
Mus musculus | |
0.183 | - |
2-Aminobenzoyl-Arg-Hyp-Gly-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
0.22 | - |
2-Aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
0.226 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Phe-Pro-Phe-Arg | - |
Mus musculus | |
0.29 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ser-Pro-Phe-Arg | - |
Mus musculus | |
0.296 | - |
2-Aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
0.331 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ala-Pro-Phe-Arg | - |
Mus musculus | |
0.402 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
1.22 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
1.38 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
2.46 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid sequence of protease domain of meprin A compared to that of meprin B, EC 3.4.24.63 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
0.00363 | - |
succinyl-Ala-Ala-Ala 4-nitroanilide | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser | Mus musculus | 2-aminobenzoyl-Arg-Gly-Pro-Phe + Ser-Pro-(4-nitro)Phe-Arg | - |
? | |
2-aminobenzoyl-Arg-Hyp-Gly-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser | Mus musculus | 2-aminobenzoyl-Arg-Hyp-Gly-Phe + Ser-Pro-(4-nitro)Phe-Arg | - |
? | |
2-aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage site: Ala-Ser | Mus musculus | 2-aminobenzoyl-Arg-Pro-Gly-Ala + Ser-Pro-(4-nitro)Phe-Arg | - |
? | |
2-aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage site: Glu-Ser | Mus musculus | 2-aminobenzoyl-Arg-Pro-Gly-Glu + Ser-Pro-(4-nitro)Phe-Arg | - |
? | |
2-aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage sites: Leu-Ser (major site) and Gly-Leu | Mus musculus | 2-aminobenzoyl-Arg-Pro-Gly-Leu + Ser-Pro-(4-nitro)Phe-Arg | major products | ? | |
2-aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrate, cleavage sites: Gly-Lys (major site) and Lys-Ser | Mus musculus | 2-aminobenzoyl-Arg-Pro-Gly + Lys-Ser-Pro-(4-nitro)Phe-Arg | major products | ? | |
2-aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O | fluorogenic bradykinin analog substrates, cleavage site: Phe-Ser | Mus musculus | 2-aminobenzoyl-Arg-Pro-Ile-Phe + Ser-Pro-(4-nitro)Phe-Arg | - |
? | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ala-Pro-Phe-Arg + H2O | chromogenic bradykinin analog | Mus musculus | Arg-Pro-Pro-Gly-(4-nitro)Phe + Ala-Pro-Phe-Arg | - |
? | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Arg-Pro-Phe-Arg + H2O | chromogenic bradykinin analog | Mus musculus | Arg-Pro-Pro-Gly-(4-nitro)Phe + Arg-Pro-Phe-Arg | - |
? | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Lys-Pro-Phe-Arg + H2O | chromogenic bradykinin analog | Mus musculus | Arg-Pro-Pro-Gly-(4-nitro)Phe + Lys-Pro-Phe-Arg | - |
? | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Phe-Pro-Phe-Arg + H2O | chromogenic bradykinin analog | Mus musculus | Arg-Pro-Pro-Gly-(4-nitro)Phe + Phe-Pro-Phe-Arg | - |
? | |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ser-Pro-Phe-Arg + H2O | i.e. nitrobradykinin, chromogenic bradykinin analog | Mus musculus | Arg-Pro-Pro-Gly-(4-nitro)Phe + Ser-Pro-Phe-Arg | - |
? | |
azocasein + H2O | - |
Mus musculus | fragments of azocasein | - |
? | |
bradykinin + H2O | one cleavage site: Phe-Ser | Mus musculus | Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg | - |
? | |
Succinyl-Ala-Ala-Ala 4-nitroanilide + H2O | arylamidolysis | Mus musculus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
2-Aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
2.4 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
4.9 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
5 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Lys-Pro-Phe-Arg | - |
Mus musculus | |
7.6 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Phe-Pro-Phe-Arg | - |
Mus musculus | |
12 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
19.6 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Arg-Pro-Phe-Arg | - |
Mus musculus | |
26.7 | - |
2-Aminobenzoyl-Arg-Hyp-Gly-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
40.9 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ser-Pro-Phe-Arg | - |
Mus musculus | |
51.5 | - |
Arg-Pro-Pro-Gly-(4-nitro)Phe-Ala-Pro-Phe-Arg | - |
Mus musculus | |
98.5 | - |
2-Aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus | |
133 | - |
2-Aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-(4-nitro)Phe-Arg | - |
Mus musculus |