Cloned (Comment) | Organism |
---|---|
gene MMP3, quantitative RT-PCR enzyme expression analysis, co-expression with GFP-RelA in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme silencing by siRNA in RAW264.7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the enzyme moves from cytoplasm to cell nucleus upon Dengue virus infection and colocalizes with NFkappaB P65 in the nucleus | Homo sapiens | 5737 | - |
extracellular | - |
Homo sapiens | - |
- |
nucleus | the enzyme moves from cytoplasm to cell nucleus upon Dengue virus infection and colocalizes with NFkappaB P65 in the nucleus | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08254 | gene MMP3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RAW-264.7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 3 | - |
Homo sapiens |
MMP3 | - |
Homo sapiens |
stromelysin-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the expression of the enzyme is upregulated in Dengue virus-infected RAW264.7 cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the intracellular Dengue virus loads are significantly higher in MMP3 silenced cells compared with controls. The expression level of selective anti-viral cytokines are decreased in MMP3 siRNA treated cells, and the transcription factor activity of NFkappaB is significantly impaired upon MMP3 silencing during Dengue virus infection | Homo sapiens |
physiological function | stromelysin-1 is a secretory endopeptidase that degrades extracellular matrices, and that promotes cellular antiviral response against Dengue virus infection. The enzyme directly interacts with NFkappaB in nucleus during Dengue virus infection and the C-terminal hemopexin-like domain of enzyme MMP3 is required for the interaction | Homo sapiens |