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Literature summary for 3.4.24.17 extracted from
- Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease (2015), Neurosci. Lett., 595, 116-121.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the enzyme, together with gelolin, is a potential biomarker for Alzheimer's disease | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P08254 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | from Alzheimer disease patients and controls | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase 3 | - |
Homo sapiens |
| MMP3 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | the enzyme activity is altered in the plasma in patients with Alzheimer's disease. Alzheimer's disease patients have significantly lower gelsolin levels and significantly higher MMP3 activity. Both the gelsolin level and MMP3 activity are significantly correlated with the mini-mental status examination, MMSE, scores | Homo sapiens |
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