Literature summary for 3.4.24.17 extracted from

Mehner, C.; Miller, E.; Khauv, D.; Nassar, A.; Oberg, A.L.; Bamlet, W.R.; Zhang, L.; Waldmann, J.; Radisky, E.S.; Crawford, H.C.; Radisky, D.C.
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma (2014), Mol. Cancer Res., 12, 1430-1439.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08254	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cancer cell	-	Homo sapiens	-
epithelial cell	-	Homo sapiens	-
PA-TU-8988T cell	transcriptional profiling, overview	Homo sapiens	-
pancreatic acinar cell	-	Homo sapiens	-
pancreatic ductal adenocarcinoma cell	the enzyme expression is associated with expression of Rac1b, a tumorigenic splice isoform of Rac1, in all stages of pancreatic cancer, analysis of 140 specimen, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP3	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	coexpression of MMP3 with activated KRAS in pancreatic acinar cells stimulates metaplasia and immune cell infiltration, priming the stromal microenvironment for early tumor development in a transgenic mouse model	Homo sapiens
physiological function	enzyme MMP3 acts as a coconspirator of oncogenic KRAS in pancreatic cancer tumorigenesis and progression, both through Rac1b-mediated phenotypic control of pancreatic cancer cells themselves, and by giving rise to the tumorigenic microenvironment, tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma, overview	Homo sapiens

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Release 2023.1 (January 2023)