Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | purified proMMP-3-catalytic domain is activated overnight in the presence of the organomercurial compound 4-aminophenyl mercuric acetate | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure analysis of the isolated catalytic enzyme domain in complex with inhibitor TIMP1, PDB ID 1UEA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tissue inhibitor of metalloproteinases 1 | TIMP-1, enzyme binding structure analysis and mechanism of inhibition, detailed overview and comparison to stromelysin-2, EC 3.4.24.22 | Homo sapiens | |
tissue inhibitor of metalloproteinases 2 | TIMP-2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme degrades a variety of extracellular matrix proteins, including collagen types III-V and fibronectin, and also activate other proteases, including MMP-1, MMP-7, MMP-8, and MMP-9 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08254 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme degrades a variety of extracellular matrix proteins, including collagen types III-V and fibronectin, and also activate other proteases, including MMP-1, MMP-7, MMP-8, and MMP-9 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-3 | - |
Homo sapiens |
MMP-3 | - |
Homo sapiens |
stromelysin-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000013 | - |
tissue inhibitor of metalloproteinases 1 | catalytic enzyme domain, pH 7.0, 37°C | Homo sapiens | |
0.00000055 | - |
tissue inhibitor of metalloproteinases 2 | catalytic enzyme domain, pH 7.0, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | despite their similar substrate specificities, the stromelysins show differential patterns of transcriptional regulation and tissue distribution that hint at distinct physiological functions in processes such as skeletal development, wound healing, and vascular remodeling | Homo sapiens |