Cloned (Comment) | Organism |
---|---|
gene mmp-3, quantitative real-time PCR expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme knockout mutants | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-asparaginyl-L-asparaginylglycyl-L-histidine | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P28862 | gene mmp-3 | - |
Mus musculus C57BL/6 | P28862 | gene mmp-3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | age-dependent increase in the central nervous system expression of MMP-3 in Twitcher mice suffering globoid cell leukodystrophy | Mus musculus | - |
glial cell | - |
Mus musculus | - |
globoid cell | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
microglia | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-3 | - |
Mus musculus |
MMP-3 | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
L-asparaginyl-L-asparaginylglycyl-L-histidine | pH and temperature not specified in the publication | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | lipopolysaccharide does not induce mmp-3 mRNA expression in peripheral blood samples | additional information |
Mus musculus | exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase-3 that mediates a morphological transformation of microglia into a multinucleated globoid cell type. But although psychosine treatment in primary purified microglial cultures moderately induces MMP-3 expression, treatment of peripheral blood or purified macrophages with equivalent concentrations of psychosine does not induce MMP-3 expression | up |
General Information | Comment | Organism |
---|---|---|
malfunction | psychosine-induced globoid cell formation from microglia is prevented by either genetic ablation or chemical inhibition of enzyme MMP-3. Elevated expression of MMP-3 in globoid cell leukodystrophy or Krabbe disease, a fatal demyelinating disease, may promote microglial responses to psychosine that may represent an important pathophysiological process in this disease and its treatment | Mus musculus |
additional information | bone marrow transplantation does not dampen elevated MMP-3 levels in globoid cell leukodystrophy-model Twitcher Mice | Mus musculus |
physiological function | matrix metalloproteinase (MMP)-3 mediates a morphological transformation of microglia into a multinucleated globoid cell type | Mus musculus |