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Literature summary for 3.4.24.17 extracted from

  • Kim, E.M.; Shin, E.J.; Lee, J.A.; Son, H.J.; Choi, D.H.; Han, J.M.; Hwang, O.
    Caspase-9 activation and Apaf-1 cleavage by MMP-3 (2014), Biochem. Biophys. Res. Commun., 453, 563-568.
    View publication on PubMed
Search for more literature for 3.4.24.17

Activating Compound

Activating Compound Comment Organism Structure
cytosolic protein Apaf-1
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
E219A site-directed mutagenesis, catalytically inactive mutant Homo sapiens
additional information overexpression of wild-type MMP-3 results in an increase in the 35 kD caspase-9 accompanied by increased caspase-9 enzymatic activity, while overexpression of mutant E219A cDNA that produces enzymatically inactive MMP-3, yields no apparent change Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Homo sapiens 5622
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosolic protein Apaf-1 + H2O Homo sapiens
-
 ?
-
 ?
pro-caspase-9 + H2O Homo sapiens activation active caspase-9 + caspase-9 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08254
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CATH.a cell
-
 Homo sapiens
-
neuronal cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosolic protein Apaf-1 + H2O
-
 Homo sapiens ?
-
 ?
cytosolic protein Apaf-1 + H2O the 130 kD full-length Apaf-1 is truncated to about 37 kD and 20 kD proteins Homo sapiens ?
-
 ?
pro-caspase-9 + H2O activation Homo sapiens active caspase-9 + caspase-9 propeptide
-
 ?
pro-caspase-9 + H2O an additional cytosolic protein, possibly Apaf-1, is required for activation, rat substrate Homo sapiens active caspase-9 + caspase-9 propeptide
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloprotease-3
-
 Homo sapiens
MMP-3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme can act inside the cell to trigger apoptosis in response to various cell stresses in dopaminergic neuronal cells. Enzyme MMP-3 activity leads to caspase-3 activation in apoptotic signaling acting upstream of caspase-9. The enzyme MMP-3 is required for the cleavage of procaspase-9 to the enzymatically active caspase-9 Homo sapiens