Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-L-tryptophan | inhibits full length stromelysin_1-477 and truncated stromelysin_100-264, enzyme binding structure and kinetics, chemical shift of the carboxylate carbon upon enzyme binding, overview. The tryptophan side chain can bind in the S1 specificity site of stromelysin with the tryptophan alpha carboxylate group coordinated to the active site zinc atom | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | the active site zinc atom of stromelysin-1 is replaced by cobalt | Homo sapiens | |
Zn2+ | metalloprotease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08254 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
stromelysin-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0063 | - |
Z-L-tryptophan | pH 6.0, 25°C, recombinant full-length enzyme stromelysin1-477, enzyme contains Zn2+ | Homo sapiens | |
0.021 | - |
Z-L-tryptophan | pH 6.0, 25°C, recombinant truncated enzyme stromelysin1-264, enzyme contains Zn2+ | Homo sapiens | |
0.03 | - |
Z-L-tryptophan | pH 6.0, 25°C, recombinant truncated enzyme stromelysin1-264, enzyme contains Co2+ | Homo sapiens | |
0.034 | - |
Z-L-tryptophan | pH 5.0, 25°C, recombinant truncated enzyme stromelysin1-264, enzyme contains Zn2+ | Homo sapiens | |
0.052 | - |
Z-L-tryptophan | pH 7.1, 25°C, recombinant truncated enzyme stromelysin1-264, enzyme contains Zn2+ | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the stromelysin-1 catalytic domain comprises residues 83-247 | Homo sapiens |