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Literature summary for 3.4.24.17 extracted from

  • Gomis-Rueth, F.X.; Maskos, K.; Betz, M.; Bergner, A.; Huber, R.; Suzuki, K.; Yoshida, N.; Nagase, H.; Brew, K.; Bourenkov, G.P.; Bartunik, H.; Bode, W.
    Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 (1997), Nature, 389, 77-81.
    View publication on PubMed

Application

Application Comment Organism
medicine proteolytic activity of the enzyme is precisely regulated by endogenous tissue inhibitors, disruption of this balance results in diseases such as arthritis, atherosclerosis, tumour growth and metastasis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
selenomethionine-substituted C-terminally truncated proMMP-3(DELTAC) expressed in Escherichia coli B834(DE3) Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
selenomethionine-substituted C-terminally truncated proMMP-3(DELTAC), sitting drop vapour-diffusion technique, crystals belong to tetragonal space group P4(3), cell axes a = b = 80.62 A, c = 157.62 A Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc endopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MMP-3
-
Homo sapiens
stromelysin-1
-
Homo sapiens