Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.16 extracted from

  • Barrett, A.J.; Dando, P.M.
    Neurolysin (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 356-360.
No PubMed abstract available
Search for more literature for 3.4.24.16

Activating Compound

Activating Compound Comment Organism Structure
additional information not activated by thiol compounds Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus
-
 Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus
EDTA
-
 Rattus norvegicus
HONHCO-CH2-CH(CH2-C6H5)CO-Ile-Ala potent and selective inhibitor of neurolysin Rattus norvegicus
additional information inhibitor of neurolysin potentiates the neurotensin-induced anti-nociception Mus musculus
Pro-Ile selective inhibitor of neurolysin, inhibition by milimolar concentrations Rattus norvegicus
Pro-Phe-PSI(PO2CH2)Gly-Pro potent and selective inhibitor of neurolysin Rattus norvegicus
Pro-Phe-PSI(PO2CH2)Leu-Pro-NH2 potent and selective inhibitor of neurolysin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Sus scrofa 5829
-
cytosol shorter form of neurolysin, lacking the cleavable mitochondrial targeting sequence, remains in the cytosol Rattus norvegicus 5829
-
mitochondrion
-
 Sus scrofa 5739
-
mitochondrion longer form of neurolysin that contains a cleavable mitochondrial targeting sequence at the N-terminus Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain
-
 Sus scrofa
-
heart
-
 Rattus norvegicus
-
heart
-
 Sus scrofa
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Sus scrofa
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
lung
-
 Rattus norvegicus
-
lung
-
 Sus scrofa
-
spleen
-
 Rattus norvegicus
-
spleen
-
 Sus scrofa
-
testis
-
 Rattus norvegicus
-
testis
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dynorphin A(1-17) + H2O
-
 Rattus norvegicus ?
-
 ?
neurotensin + H2O cleavage at the Pro-Tyr bond Rattus norvegicus ?
-
 ?
Pz-Pro-Leu-Gly-Pro-D-Arg + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Rattus norvegicus

Synonyms

Synonyms Comment Organism
endopeptidase 24.16
-
 Rattus norvegicus
Microsomal endopeptidase
-
 Rattus norvegicus
oligopeptidase M
-
 Rattus norvegicus
soluble angiotensin II-binding protein
-
 Rattus norvegicus
thimet oligopeptidase II neurolysin is most likely to be confused with thimet oligopeptidase II, but it is distinguished by its lack of activation by thiol compounds, inhibition by millimolar concentrations of Pro-Ile, cleavage of neurotensin at the Pro-Tyr bond, and different mobility in column chromatography Rattus norvegicus