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Literature summary for 3.4.24.16 extracted from

  • Vincent, B.; Dauch, P.; Vincent J.P.; Checler, F.
    Stably transfected human cells overexpressing rat brain endopeptidase 3.4.24.16: biochemical characterization of the activity and expression of soluble and membrane-associated counterparts (1997), J. Neurochem., 68, 837-845.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in human kidney cells, HK293 cells. The transfectants exhibit a membrane-associated form of endopeptidase-24.16, the catalytic site of which clearly faces the extracellular domain. Transfected cells are unable to secrete the enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Rattus norvegicus
acetyl-neurotensin(8-13) inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
angiotensin I inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
angiotensin II degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
bradykinin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
dithiothreitol
-
Rattus norvegicus
dynorphin(1-8) degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
dynorphin(1-9) degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
EDTA
-
Rattus norvegicus
kinetensin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-4-aminobenzoate
-
Rattus norvegicus
Neuromedin N degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
neurotensin inhibits degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
Pro-DL-Phe-Psi(PO2CH2)-Gly-Pro-NH2
-
Rattus norvegicus
Pro-Ile
-
Rattus norvegicus
Substance P degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus
Xenopsin degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the transfectants exhibit a membrane-associated form of endopeptidase-24.16, the catalytic site of which clearly faces the extracellular domain Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is likely involved in the physiological termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-methoxycoumarin-3-carboxylyl-Pro-Leu-Gly-Pro-Lys-dinitrophenyl + H2O
-
Rattus norvegicus ?
-
?
additional information the enzyme is likely involved in the physiological termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract Rattus norvegicus ?
-
?