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Literature summary for 3.4.24.14 extracted from
- Critical role of ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2) in cardiac hypertrophy induced by pressure overload (2017), Hypertension, 69, 1060-1069 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of ADAMTS2-KO mice, phenotype, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Rattus norvegicus | - |
- |
| extracellular | - |
Homo sapiens | - |
- |
| extracellular | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen I + H2O | Rattus norvegicus | - |
? | - |
? |  |
| procollagen I + H2O | Homo sapiens | - |
? | - |
? | |
| procollagen I + H2O | Mus musculus | - |
? | - |
? | |
| procollagen II + H2O | Rattus norvegicus | - |
? | - |
? | |
| procollagen II + H2O | Homo sapiens | - |
? | - |
? | |
| procollagen II + H2O | Mus musculus | - |
? | - |
? | |
| procollagen III + H2O | Rattus norvegicus | - |
? | - |
? | |
| procollagen III + H2O | Homo sapiens | - |
? | - |
? | |
| procollagen III + H2O | Mus musculus | - |
? | - |
? | |
| procollagen V + H2O | Rattus norvegicus | - |
? | - |
? | |
| procollagen V + H2O | Homo sapiens | - |
? | - |
? | |
| procollagen V + H2O | Mus musculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95450 | - |
- |
| Mus musculus | Q8C9W3 | - |
- |
| Rattus norvegicus | P16636 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | cultured neonatal rat cardiomyocytes (NRCMs) | Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| heart | upregulated expression of ADAMTS2 in failing human hearts, expression analysis of ADAMTS2 in human heart samples from patients with dilated cardiomyopathy and from healthy donors | Homo sapiens | - |
| heart | upregulated expression of ADAMTS2 in hypertrophic murine hearts | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen I + H2O | - |
Rattus norvegicus | ? | - |
? | |
| procollagen I + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen I + H2O | - |
Mus musculus | ? | - |
? | |
| procollagen II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| procollagen II + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen II + H2O | - |
Mus musculus | ? | - |
? | |
| procollagen III + H2O | - |
Rattus norvegicus | ? | - |
? | |
| procollagen III + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen III + H2O | - |
Mus musculus | ? | - |
? | |
| procollagen V + H2O | - |
Rattus norvegicus | ? | - |
? | |
| procollagen V + H2O | - |
Homo sapiens | ? | - |
? | |
| procollagen V + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS2 | i.e. a disintegrin and metalloproteinase with thrombospondin motifs 2 | Rattus norvegicus |
| ADAMTS2 | i.e. a disintegrin and metalloproteinase with thrombospondin motifs 2 | Homo sapiens |
| ADAMTS2 | i.e. a disintegrin and metalloproteinase with thrombospondin motifs 2 | Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | upregulated expression of ADAMTS2 in failing human hearts | up |
| Mus musculus | upregulated expression of ADAMTS2 in hypertrophic murine hearts | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mice lacking ADAMTS2 display exacerbate cardiac hypertrophy on pressure overload-induced hypertrophic response, whereas mice with cardiac-specific overexpression of ADAMTS2 display alleviation of this detrimental phenotype. A murine model of aortic banding (AB)-induced cardiac hypertrophy, shows that mice after 4-week AB-treatment exhibit dramatically increased ADAMTS2 protein expression. Loss of ADAMTS2 (ADAMTS2-KO mice) aggravates pressure overload-induced hypertrophy | Mus musculus |
| malfunction | overexpression of ADAMTS2 in cultured neonatal rat cardiomyocytes (NRCMs) results in markedly decreased cell sizes compared with those of cells in the control group | Rattus norvegicus |
| physiological function | ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens. ADAMTS2 regulates the hypertrophic response through inhibiting the activation of the PI3K/AKT-dependent signaling pathway | Homo sapiens |
| physiological function | ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens. ADAMTS2 regulates the hypertrophic response through inhibiting the activation of the PI3K/AKT-dependent signaling pathway. ADAMTS2 decreases AKT phosphorylation on hypertrophic stress | Mus musculus |
| physiological function | ADAMTS2 (a disintegrin and metalloproteinase with thrombospondin motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens. ADAMTS2 regulates the hypertrophic response through inhibiting the activation of the PI3K/AKT-dependent signaling pathway. ADAMTS2 modulates Ang II-induced cultured neonatal rat cardiomyocytes (NRCMs) hypertrophy in vitro | Rattus norvegicus |
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