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Literature summary for 3.4.24.11 extracted from

  • Morisaki, N.; Ohuchi, A.; Moriwaki, S.
    The role of neprilysin in regulating the hair cycle (2013), PLoS ONE, 8, e55947.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N-phenethylphosphonyl-L-leucyl-L-tryptophan NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase Homo sapiens
N-phenethylphosphonyl-L-leucyl-L-tryptophan NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase Mus musculus
N-phenethylphosphonyl-L-leucyl-L-tryptophan NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase Rattus norvegicus
phosphoramidon a typical inhibitor for metalloproteinase Homo sapiens
phosphoramidon a typical inhibitor for metalloproteinase Mus musculus
phosphoramidon a typical inhibitor for metalloproteinase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular extracellular matrix Homo sapiens
-
-
extracellular extracellular matrix Rattus norvegicus
-
-
extracellular extracellular matrix Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metallo-endopeptidase Homo sapiens
additional information metallo-endopeptidase Rattus norvegicus
additional information metallo-endopeptidase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
?
-
?
Elastin + H2O Rattus norvegicus
-
?
-
?
Elastin + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08473
-
-
Mus musculus Q61391
-
-
Rattus norvegicus P07861
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
fibroblast
-
Rattus norvegicus
-
fibroblast
-
Mus musculus
-
hair follicle
-
Mus musculus
-
hair follicle extracellular matrix, dermal papilla, and follicular epithelium Rattus norvegicus
-
hair follicle hair follicles are isolated from occipital scalp specimens, enzyme is localized in extracellular matrix, dermal papilla, and follicular epithelium, and during all stages of the hair cycle Homo sapiens
-
hair follicle epithelium
-
Homo sapiens
-
hair follicle epithelium
-
Rattus norvegicus
-
hair follicle epithelium
-
Mus musculus
-
skin
-
Mus musculus
-
skin the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle Homo sapiens
-
skin the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
Homo sapiens ?
-
?
Elastin + H2O
-
Rattus norvegicus ?
-
?
Elastin + H2O
-
Mus musculus ?
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
-
Homo sapiens glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
-
Rattus norvegicus glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
-
Mus musculus glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
-
?

Synonyms

Synonyms Comment Organism
CALLA
-
Homo sapiens
CALLA
-
Rattus norvegicus
CALLA
-
Mus musculus
CD10
-
Homo sapiens
CD10
-
Rattus norvegicus
CD10
-
Mus musculus
membrane metallo-endopeptidase
-
Rattus norvegicus
MME
-
Rattus norvegicus
NEP
-
Homo sapiens
NEP
-
Rattus norvegicus
NEP
-
Mus musculus
skin fibroblast elastase
-
Homo sapiens
skin fibroblast elastase
-
Rattus norvegicus
skin fibroblast elastase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus
37
-
assay at Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000008
-
pH not specified in the publication, 37°C Homo sapiens N-phenethylphosphonyl-L-leucyl-L-tryptophan

General Information

General Information Comment Organism
malfunction inhibitor N-phenethylphosphonyl-L-leucyl-L-tryptophane-treated mouse skin elastic fibers surrounding early anagen hair cycle phase hair bulbs seem to accumulate more than in vehicle-treated mouse skin Mus musculus
physiological function the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity Homo sapiens
physiological function the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity Rattus norvegicus
physiological function the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity Mus musculus