Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-phenethylphosphonyl-L-leucyl-L-tryptophan | NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase | Homo sapiens | |
N-phenethylphosphonyl-L-leucyl-L-tryptophan | NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase | Mus musculus | |
N-phenethylphosphonyl-L-leucyl-L-tryptophan | NPLT, synthesis of the phosphoramidon derivative with enhanced permeability into the skin that shows inability to inhibit type I and type IV collagenase, but inhibits fibroblast elastase | Rattus norvegicus | |
phosphoramidon | a typical inhibitor for metalloproteinase | Homo sapiens | |
phosphoramidon | a typical inhibitor for metalloproteinase | Mus musculus | |
phosphoramidon | a typical inhibitor for metalloproteinase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | extracellular matrix | Homo sapiens | - |
- |
extracellular | extracellular matrix | Rattus norvegicus | - |
- |
extracellular | extracellular matrix | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metallo-endopeptidase | Homo sapiens | |
additional information | metallo-endopeptidase | Rattus norvegicus | |
additional information | metallo-endopeptidase | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | - |
? | - |
? | |
Elastin + H2O | Rattus norvegicus | - |
? | - |
? | |
Elastin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08473 | - |
- |
Mus musculus | Q61391 | - |
- |
Rattus norvegicus | P07861 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
fibroblast | - |
Rattus norvegicus | - |
fibroblast | - |
Mus musculus | - |
hair follicle | - |
Mus musculus | - |
hair follicle | extracellular matrix, dermal papilla, and follicular epithelium | Rattus norvegicus | - |
hair follicle | hair follicles are isolated from occipital scalp specimens, enzyme is localized in extracellular matrix, dermal papilla, and follicular epithelium, and during all stages of the hair cycle | Homo sapiens | - |
hair follicle epithelium | - |
Homo sapiens | - |
hair follicle epithelium | - |
Rattus norvegicus | - |
hair follicle epithelium | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
skin | the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle | Homo sapiens | - |
skin | the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Elastin + H2O | - |
Mus musculus | ? | - |
? | |
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O | - |
Homo sapiens | glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide | - |
? | |
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O | - |
Rattus norvegicus | glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide | - |
? | |
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O | - |
Mus musculus | glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CALLA | - |
Homo sapiens |
CALLA | - |
Rattus norvegicus |
CALLA | - |
Mus musculus |
CD10 | - |
Homo sapiens |
CD10 | - |
Rattus norvegicus |
CD10 | - |
Mus musculus |
membrane metallo-endopeptidase | - |
Rattus norvegicus |
MME | - |
Rattus norvegicus |
NEP | - |
Homo sapiens |
NEP | - |
Rattus norvegicus |
NEP | - |
Mus musculus |
skin fibroblast elastase | - |
Homo sapiens |
skin fibroblast elastase | - |
Rattus norvegicus |
skin fibroblast elastase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
pH not specified in the publication, 37°C | Homo sapiens | N-phenethylphosphonyl-L-leucyl-L-tryptophan |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibitor N-phenethylphosphonyl-L-leucyl-L-tryptophane-treated mouse skin elastic fibers surrounding early anagen hair cycle phase hair bulbs seem to accumulate more than in vehicle-treated mouse skin | Mus musculus |
physiological function | the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity | Homo sapiens |
physiological function | the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity | Rattus norvegicus |
physiological function | the role of neprilysin in regulating the hair cycle, a cyclic process of growing, regressing and resting phases, i.e. anagen, catagen, and telogen, respectively. The enzyme degrades elastin, which is associated with skin elasticity | Mus musculus |